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Tissue Distribution Studies with Radioactive Manganese: A Potential Agent for Myocardial Imaging

Veterans Administration Hospital and University of California School of Medicine, San Diego, California

Correspondence: For reprints contact: Heinrich R. Schelbert, Div. of Nuclear Medicine, University of California Medical Center, 225 W. Dickinson St., San Diego, CA 92103.

ABSTRACT

Manganese, a trace metal, is known to localize in mitochondria. Because mitochondria are abundant in heart muscle, the possible utility of radioactive manganese as a myocardial imaging agent was examined in 25 rats and six dogs. Myocardial uptake of Mn-54 in rats was found to exceed that of thallium-201; myocardium-to-blood ratios averaged 306:1 versus 48:1 for Tl-201. In the dog, uptake of Mn-54 by ischemic myocardium was reduced by 17–75% compared with normal myocardium. Thus, radioactive manganese appears promising as an intravenous myocardial imaging agent, and might be useful in studying the function of myocardial mitochondria by external imaging.

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