HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Williams, C. C. Articles by Gabel, M. Search for Related Content PubMed PubMed Citation Articles by Williams, C. C. Articles by Gabel, M.

A Comparison of Technetium Etidronate and Pyrophosphate for Acute Myocardial Infarct Imaging

University of Cincinnati College of Medicine and Nuclear Medicine Laboratory, Bureau of Radiological Health, Food and Drug Administration, Cincinnati, Ohio

Correspondence: For reprints contact: Craig C. Williams, Radioisotope Laboratory, University of Cincinnati College of Medicine, Cincinnati, OH 45267.

ABSTRACT

Etidronate and pyrophosphate, labeled with Tc-95m and Tc-99m, were studied in experimentally infarcted mongrel dogs. A distribution study was conducted 2 hr after simultaneous administration of both agents in two groups of dogs. In one group, the injection was made 15 min after release of a 2-hr coronary arterial ligation. Another group was injected 48 hr after release of the ligation. The uptakes for each radiopharmaceutical and the ratio of uptakes for each sample were computed. The data show pyrophosphate to be a superior agent for the imaging of acute myocardial infarcts because of the higher uptake by infarcted myocardium and the greater contrast between infarcted myocardium and neighboring organs.