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Determination of Radionuclide Concentrations with Positron CT Scanning (PETT): Concise Communication

Mallinckrodt Institute of Radiology, St. Louis, Missouri

Correspondence: For reprints contact: John Eichling, The Edward Mallinckrodt Institute, 510 S. Kingshighway Blvd., St. Louis, MO 63110.

ABSTRACT

A series of experiments was undertaken to evaluate the response of a positron emission transverse tomograph (PETT) to measured radionuclide concentrations similar to those encountered in human studies. The correlation between the response of the imaging system (mean PETT number/min), and the concentration of the radioactivity producing the output data, was linear with a computed sensitivity of 2720 PETT number/min, per µCi/ml, per picture element, for a radionuclide (100% ß⁺) contained in either of two phantoms and imaged with a resolution of 1.5 cm. It was concluded that the output data are essentially independent of the imaged object's physical dimensions for the range of 18–28-cm diam and faithfully reflect the regional radioactivity concentration within the object, provided valid attenuation correction is achieved and the sampled area is not compromised by the imaging system's limitations of spatial resolution.

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