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Pharmacokinetics of Technetium-99m Diphosphonate

Frank P. Castronovo^*,, Milton J. Guiberteau, Gerald Berg, Kenneth A. McKusick^*, Ronald J. Callahan^* and Majic S. Potsaid^*

Massachusetts General Hospital, Boston, Massachusetts
Waterbury Hospital, Waterbury, Connecticut

Correspondence: For reprints contact: Frank P. Castronovo, Dept. of Radiology, Massachusetts General Hospital, Boston MA 02114.

ABSTRACT

Increased diagnostic information may be derived with Tc-99m diphosphonate from a detailed kinetic analysis of blood disappearance, urinary excretion, and quantitative assessment of skeletal uptake. Blood and urine determinations were studied in three populations: normal volunteers, patients with negative bone scans, and patients with positive bone scans. Quantitative imaging studies were performed in normal volunteers and patients with a scintillation camera interfaced to a computer. All subjects were scanned in the lower lumbar region up to 1 hr after Tc-99m diphosphonate administration. Blood levels exhibited a triexponential clearance pattern. Significant (p < 0.05) differences were observed for the 5-min blood and 0–1 hr urine values among the various groups. The computer-generated images showed an initial early uptake in bone, kidneys and soft tissue. Thereafter, a parallel fall-off in activity was observed in kidney and soft tissue, with a concomitant increase in bone. Skeletal uptake was different for normal and diseased bone.

FOOTNOTES

^* Department of Radiology, Massachusetts General Hospital, Boston, Mass.

Active Duty, US Army.

Department of Radiology, Waterbury Hospital, Waterbury, Conn.