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Clinical Evaluation of Some Phosphorus Bone-Imaging Agents: Concise Communication

Vanderbilt University, Nashville, Tennessee

Correspondence: For reprints contact: John R. Van Wazer, Vanderbilt University, Nashville, TN 37235.

ABSTRACT

Four different Tc-99m labeled phosphorus-based bone-imaging agents were compared by a scan-evaluation technique in which the skeletal uptake was visually assessed at selected sites. A detailed statistical analysis of scans, by each of three independent evaluators, on a total of 140 different patients showed that two of the agents (based on pyro- and on trimetaphosphate) were superior. The statistical analysis showed good agreement between the investigators and consistency in their repeat evaluations.