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Technetium-99m Phytate as a Bone-Marrow Imaging Agent: Biodistribution Studies in Animals: Concise Communication

Armed Forces Radiobiology Research Institute, Bethesda, Maryland
The Johns Hopkins Medical Institutions, Baltimore, Maryland

Correspondence: For reprints contact: Robert G. Hamilton, Armed Forces Radiobiology Research Institute, National Naval Medical Center, Bethesda, MD 20014.

ABSTRACT

Technetium-99m phytate has been suggested as a bone-marrow imaging agent. This article compares the biodistribution of Tc-99m labeled "bone marrow" phytate, sulfur colloid, and diphosphonate in young rats and rabbits. Autoclaved bone marrow phytate revealed significant long-base deposition, but 96% of this activity was associated with compact bone and only 4% with bone marrow. This distribution is similar to that of diphosphonate, but significantly different from that of sulfur colloid. Technetium-99m-phytate is not recommended as a bone-marrow imaging agent.