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Evaluation of Formamidine Sulfinic Acid and Other Reducing Agents For Use in The Preparation of Tc-99m Labeled Radiopharmaceuticals

Vancouver General Hospital, Vancouver, British Columbia, Canada

Correspondence: For reprints contact: D. M. Lyster, Div. of Nuclear Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada, V5Z 1M9.

ABSTRACT

Various reducing agents have been evaluated for their potential usefulness in the preparation of ^99mTc labeled radiopharmaceuticals for use in nuclear medicine. Adequate labeling of various radiopharmaceuticals was accomplished using formamidine sulfinic acid. Nitrogen-purging of solutions is not required, which is an advantage for in-house preparation. Tagging requires heating, however, so heat-labile material cannot be used. Various compounds that could not be labeled when stannous chloride was used, could be tagged with ^99mTc when formamidine sulfinic acid was used as the reducing agent.

FOOTNOTES

^* Presently at the University of Colorado, Denver, Colorado.