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Biochemistry of Metalocenes. I. Distribution of ⁵⁹Fe or ¹⁰³Ru-Labeled Metalocene Carboxylic Acid in Mice

Pharmazeutisches Institut der Freien Universität Berlin

Correspondence: For reprints contact: M. Wenzel, Freie Universität, #D 1 Berlin-Dahlem, Königin-Luise-Str. 2-4, Germany.

ABSTRACT

Metalocene carboxylic acids labeled with ⁵⁹Fe or ¹⁰³Ru were administered to mice and the organ distributions and amounts of label excreted were determined. Both metalocenes were excreted approximately 90 times faster than the respective inorganic chlorides ⁵⁹FeCl₃ or ¹⁰³RuCl₃. The metalocenes showed an extremely high kidney-to-muscle ratio (up to 1,000). ^99mTc-labeled renal agents, tested for comparison, showed lower ratios. Retention of radioactivity in blood and the presence of free iron in urine indicate that the ferrocene derivative is degraded in vivo, but the ruthenocene analog is not.

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