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Myocardial Infarct Imaging Agents. III. Synthesis and Evaluation of [²⁰³Hg] Hydroxymercuriphthaleins

Harvard Medical School and Northeastern University, Boston, Massachusetts

Correspondence: For reprints contact: Michael A. Davis, Dept. of Radiology, Harvard Medical School, 50 Binney Street, Bonton, Massachusetts 02115.

ABSTRACT

Four Hg-203-mercurated phthaleins were prepared, purified, and compared with [²⁰³Hg] mercuric nitrate, [³H] phenolphthalein, [²⁰³Hg] hydroxymercurifluorescein and Tc-99m-pyrophosphate in a rat model of myocardial necrosis to determine their specificities for damaged myocardium. The ratios of damaged myocardium to normal myocardium, and to blood, for the [²⁰³Hg] hydroxymercuriphthaleins (20.7–34.1 and 12.1–20.1, respectively) were somewhat lower than those reported previously for [²⁰³Hg] hydroxymercurifluorescein, but were higher than those found with [²⁰³Hg] mercuric nitrate, [³H] phenolphthalein, and Tc-99m pyrophosphate. Both the hydroxymercuri- functional group and the phthalein moiety are required for selectivity. The removal of the oxygen bridge present in fluorescein, and the replacement of carboxylic acid by sulfonic acid, had no significant effects on the sequestration process in damaged tissue.