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Technetium-99m Glucoheptonate in Brain-Tumor Detection: An Important Advance in Radiotracer Techniques

Hôtel-Dieu Hospital, University of Montreal, Montreal, Canada

Correspondence: For reprints contact: Jean Léveillé, Nuclear Medicine, Hôtel-Dieu Hospital, 3840 St.-Urbain St., Montreal, Qué, Canada H2W 1T8.

ABSTRACT

We have compared [Tc-99m] sodium pertechnetate with Tc-99m glucoheptonate in 52 patients studied for various brain lesions. Flow studies as well as delayed scans were performed in all. Especially in primary and metastatic lesions of the posterior fossa, the diagnostic yield was improved by the delayed glucoheptonate (GH) scans. In contrast, no advantage of GH over pertechnetate could be detected in the study of infarcts or other ischemic lesions. Various hypotheses are discussed to explain the observed differences in behavior between the two tracers.