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The Journal of Nuclear Medicine Vol. 18 No. 10 1005-1009
© 1977 by Society of Nuclear Medicine
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Myocardial Uptake of Tc-99m Skeletal Agents in the Rat after Experimental Induction of Microscopic Foci of Injury

D. G. Miller, R. F. Gilmour, Z. D. Grossman, S. Mallov, B. W. Wistow and R. F. Rohner

State University of New York, Syracuse, New York

Correspondence: For reprints contact: Dean G. Miller, Dept. of Pharmacology, State University of New York, Upstate Medical Center, 766 Irving Ave., Syracuse, NY 13210.

ABSTRACT

The cardiac uptake of Tc-99m tagged skeletal agents was studied after myocardial injury produced by subcutaneous catecholamine injection and random foot-shock stress. Rats stressed for 2 hr developed microfocal myocardial injury, without gross change, whereas those stressed for 12 hr sustained more confluent and sometimes grossly visible damage. Tc-99m MDP and Tc-99m PPi concentrations in these hearts were significantly above control (undamaged) heart levels, producing positive gamma-camera images. Subcutaneous epinephrine injections resulted in grossly visible lesions, with tracer concentrations higher than those previously reported in vaso-occlusive infarcts.

We postulate that the stress-induced scattered microfocal lesions may accumulate radiopharmaceutical on a per-gram basis in the same way as the larger catecholamine-induced lesions, since tracer delivery to the injured areas in each case is probably less impeded than in frankly vaso-occlusive models. Such microfoci, then, could provide an explanation for some of the "false positive" myocardial scans observed clinically.






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Copyright © 1977 by the Society of Nuclear Medicine.