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A Radioiodinated Bretylium Analog as a Potential Agent for Scanning the Adrenal Medulla

University of Michigan, Ann Arbor, Michigan

Correspondence: For reprints contact: R. E. Counsell, Dept. of Pharmacology, Medical School, University of Michigan, Ann Arbor, MI 48109.

ABSTRACT

Studies with radioiodinated bretylium analogs (RIBA) suggested that the p-isomer was capable of concentrating in adrenal medulla. The present studies with ¹²⁵I-p-RIBA in rats and dogs confirm this property and show its marked and persistent affinity for the adrenal medulla. Analogous studies with ¹⁴C-p-IBA indicate that it is the quaternary form of the drug that is retained by the adrenal and that high thyroidal radioactivity following ¹²⁵I-p-RIBA administration is due to in vivo deiodination of the drug.