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Myocardial Uptake (Rabbit) of Six ^99mTc-Tagged Pharmaceuticals and ⁸⁵Sr after Vasopressin-Induced Necrosis

State University Hospital, State University of New York, Syracuse, New York

Correspondence: For reprints contact: Zachary D. Grossman, Dept. of Radiology, SUNY Upstate Medical Center, 750 E. Adams St., Syracuse, NY 13210.

ABSTRACT

A new rapid method for producing myocardial necrosis in rabbits was developed, using percutaneous intramyocardial injection of vasopressin in peanut oil. The 15-min procedure resulted in a mortality rate of 15% and a success rate among surviving animals of 50%. When the lesions were 24 hr old, strontium-85 and a technetium-99m-tagged agent were injected intravenously simultaneously, and the animals were killed 1, 6, and 24 hr later for tissue radioassay. Strontium-85 failed to accumulate appreciably in the lesions. Three bone-seeking technetium complexes (pyrophosphate, methylene diphosphonate, and imidodiphosphonate) produced lesion-to-normal myocardial ratios of 6, 5, and 14, respectively, at 1 hr, and 20, 30, and 33 at 6 hr. The ratios for ^99mTc-glucoheptonate were only 2 at 1 hr and 4 at 6 hr, while the ratios of ^99mTc-acetylcysteine and ^99mTc-citrate were even lower.