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Radiopharmaceuticals. XIX. ¹¹C-Labeled Octylamine, a Potential Diagnostic Agent for Lung Structure and Function

Brookhaven National Laboratory, Upton, New York

Correspondence: For reprints contact: Joanna Fowler, Dept. of Chemistry, Brookhaven National Laboratory, Upton, NY 11973.

ABSTRACT

After intravenous injection, ¹¹C-octylamine. HCl is rapidly sequestered by the rabbit lung. The initial lung uptake during the first minute was 70 ± 6% of the administered dose, and 40% of the injected dose remained after 15 min. Approximately 12% of the administered radioactivity is exhaled as ¹¹CO during the first 30 min.