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Carboxyl-Labeled ¹¹C-1-Aminocyclopentanecarboxylic Acid, a Potential Agent for Cancer Detection

Oak Ridge Associated Universities and Oak Ridge National Laboratory, Oak Ridge, Tennessee

Correspondence: For reprints contact: R. L. Hayes, Medical and Health Sciences Division, Oak Ridge Associated Universities, P. O. Box 117, Oak Ridge, TN 37830.

ABSTRACT

Carboxyl-labeled ¹¹C-1-aminocyclopentanecarboxylic acid (¹¹C-ACPC) has been prepared in multimillicurie amounts. The conversion of H¹¹CN to ¹¹C-ACPC(t_1/2 = 20.4 min) was accomplished by a rapid (20-min) two step high-temperature modification of the Bücherer-Strecker amino acid synthesis technique, which should be applicable at other accelerator installations. Purification was by ion exchange techniques. Animal studies have indicated that ¹¹C-ACPC is a potential tumor-localizing agent for detecting cancer in humans by nuclear medicine scanning techniques.