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Relationship between Bone Uptake of ^99mTc-Pyrophosphate and Hydroxyproline in Blood and Urine

Montreal General Hospital, Montreal, Canada

Correspondence: For reprints contact: Thomas Wiegmann, Div. of Nephrology, Dept. of Medicine, Montreal General Hospital, 1650 Cedar Ave., Montreal, Quebec H3G 1A4, Canada.

ABSTRACT

In a group of hospital patients with various diseases, the urinary hydroxyproline-to-creatinine ratio showed a significant correlation (r = 0.63; p < 0.001) with the 5-hr bone-to-soft-tissue ratio for ^99mTc-pyrophosphate uptake. In patients on chronic hemodialysis, a similar correlation was found between the 5-hr bone-to-soft-tissue ratio and hydroxyproline levels in plasma and serum. The findings suggest that ^99mTc-pyrophosphate binding by bone is related to collagen metabolism.