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The Effect of Carrier Technetium in the Preparation of ^99mTc-Human Serum Albumin

William Beaumont Hospital, Royal Oak, Michigan

Correspondence: For reprints contact: W. C. Porter, Nuclear Pharmacy, Dept. of Nuclear Medicine, William Beaumont Hospital, Royal Oak, MI 48072.

ABSTRACT

Accumulation of daughter ⁹⁹Tc in ^99mMo- ^99mTc generator systems may adversely affect the preparation of certain ^99mTc radiopharmaceuticals. In a study of the effect of "carrier" technetium on the radiochemical purity of ^99mTc human serum albumin, varying amounts of ⁹⁹Tc were added to a commercially available electrolytic kit. The maximum amount of ⁹⁹Tc that could be added to such a kit and still maintain radiochemical purity above 90% was about 3 x 10¹⁵ atoms. When kits containing 10^{16 99}Tc atoms were electrolyzed for the conventional 42 sec, the radiochemical purity was only 50.8%. However, when the electrolysis time was varied, it was found that electrolysis for 80 sec yielded a product with greater than 90% radiochemical purity. Four solutions to the problem created by the ⁹⁹Tc carrier effect are described.