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Tomographic Images of Blood Pool and Perfusion in Brain and Heart

Mallinckrodt Institute of Radiology and Washington University School of Medicine, St. Louis, Missouri

Correspondence: For reprints contact: M. Phelps, Dept. of Radiology, 1st Floor Donner Center, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104.

ABSTRACT

A whole-body positron-emission transaxial tomograph (PETT III) was to image the cross-sectional distribution of ¹³NH₃ and ¹¹CO-hemoglobin in the human brain and heart. Carotid and intravenous bolus injections of ¹³NH₃ in the rhesus monkey had shown that ¹³NH₃ is efficiently extracted by the brain and clears from it slowly (half-time, 40–50 min for carotid injections and 60–70 min for intravenous injections). The intravenous tomographic images in humans showed an excellent relationship between ¹³NH₃ uptakes in the cortex, subcortical white matter, cerebellum, and brain stem and normal blood perfusion or flow in these structures. Cerebral lesions with high (metastasis) and low (stroke) blood flows showed correspondingly high and low uptakes of ¹³NH₃. Large- and small-vascular structures of the brain were also clearly seen in ¹¹CO-hemoglobin tomographic images. Normal myocardium and the ventricular chambers were well defined, and a transmural anterior myocardial infarct was clearly shown. The effective combination of positron transaxial tomography and compounds labeled with positron-emitters provides a safe new method for quantitatively imaging hemodynamic and physiologic functions of selected organs with tomographic image quality.

FOOTNOTES

^* Present address: Dept. of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104.

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