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Preparation and Use of ¹²³I-Labeled Highly Iodinated Fibrinogen for Imaging Deep-Vein Thrombi

Mallinckrodt Institute of Radiology, St. Louis, Missouri

Correspondence: For reprints contact: John F. Harwig, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd., St. Louis, Mo. 63110.

ABSTRACT

A method for producing protein-iodination-grade ¹²³I suitable for use with a compact biomedical cyclotron is reported. The preparation of highly iodinated fibrinogen (25 ¹²³I atoms per molecule) is described, and its successful use as a thrombus-imaging agent in experimental animals is reported. This new agent clears from the blood faster than conventional radioiodinated fibrinogen and gives higher thrombus-to-blood activity ratios. Thus, the detection of deep-vein thrombi in areas of large blood pool is enhanced, and images can be obtained sooner after administration of the radiopharmaceutical. Induced 4–8-hr-old femoral-vein thrombi in dogs can be well visualized with a scintillation camera as early as 4 hr and as late as 15 hr after administration of 1 mCi of ¹²³I-labeled highly iodinated fibrinogen.