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A New Preparation Method for ^99mTc-Phytate

Dainabot Radioisotope Laboratories, Tokyo, Japan

Correspondence: For reprints contact: Isao Ikeda, Dainabot Radioisotope Laboratories, 1-2-8 Hatchobori, Chuo-ku, Tokyo, Japan.

ABSTRACT

A new method is described in which Pt-Sn or Sn-Sn electrodes are used to activate ^99mTcO₄^–. The ^99mTc is incorporated into phytic acid by stannous ion released from a tin anode by the corrosive reaction. The most suitable pH for labeling phytic acid by this method was below 5 and the ^99mTc-phytate formed could be precipitated with Ca⁺² at a pH above 3.5. Though ^99mTc-phytate is soluble in aqueous solution, it forms an insoluble species with Ca⁺² in vivo and is trapped in the reticuloendothelial system. More than 93% of the ^99mTc-phytate localized in the liver of mice; here its biologic half-time is about 112 hr. The ^99mTc-phytate prepared by this method promises to be useful as a liver-scanning agent. Since our method does not require an applied electric potential, it appears to be one of the most convenient methods for labeling compounds with ^99mTc.