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Possible Enhancement of ⁶⁷Ga-Citrate Imaging by Iron Dextran

Johns Hopkins Medical Institutions, Baltimore, Maryland

Correspondence: For reprints contact: Zvi H. Oster, Johns Hopkins Medical Institutions, Div. of Nuclear Medicine and Radiation Health, 615 N. Wolfe St., Baltimore, Md. 21205.

ABSTRACT

The whole-body retention of ⁶⁷Ga-citrate was studied in intact and in abscess-bearing rabbits. The abscess-to-muscle ratio was obtained using a data processor. Administration of iron dextran lowers the whole-body retention in both the intact and abscess-bearing animals. The optimum time for administering the iron dextran was 24 hr after the ⁶⁷Ga-citrate injection. At this time, the abscess-to-muscle ratio was highest and the cathode-ray screen images showed lowered background activity and much better definition of the lesion.