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Chemistry of ^99mTc Tracers. II. In Vitro Conversion of Tagged HEDP and Pyrophosphate (Bone-Seekers) into Gluconate (Renal Agent). Effects of Ca and Fe(II) on In Vivo Distribution

Donner Laboratory and Lawrence Berkeley Laboratory, University of California, Berkeley, California, and Howard University, Washington, D.C.

Correspondence: For reprints contact: James McRae, Donner Laboratory, Univ. of California, Berkeley, Calif. 94720.

ABSTRACT

Sodium gluconate transforms the bone-seekers ^99mTc-HEDP and ^99mTc-pyrophosphate into the renal agent ^99mTc-gluconate. In these in vitro processes, pyrophosphate is displaced faster than HEDP, white the HEDP reaction is accelerated by calcium ions. The in vivo distributions of these bone and kidney agents are altered by the prior local injection of calcium or iron (II). These transformation and translocation phenomena are explained in terms of the mechanistic behavior of Tc(IV) complexes.