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Rat Model for Acute Myocardial Infarction: Application to Technetium-Labeled Glucoheptonate, Tetracycline, and Polyphosphate

New England Nuclear Corporation, North Billerica, Massachusetts

Correspondence: For reprints contact: L. L. Camin, New England Nuclear Corp., Radiopharmaceutical Div., Research Dept., North Billerica, Mass. 01862.

ABSTRACT

Cauterization of rat myocardium serves as a quick (2 min) inexpensive technique to create an animal model of acute myocardial infarction useful in evaluating radiopharmaceuticals as potential clinical imaging agents. Preliminary evidence indicates that it correlates well with behavior in man. Application of the model led to the discovery, confirmed by later investigators, that chelating agents such as glucoheptonate and polyphosphate show significant uptake in recent myocardial lesions.

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