HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Levine, G. Articles by Gumerman, L. W. Search for Related Content PubMed PubMed Citation Articles by Levine, G. Articles by Gumerman, L. W.

Influence of Dimercaprol on the Early Hepatic Uptake of ¹¹¹In-Bleomycin in the BALB/c Mouse

University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Correspondence: For reprints contact: Geoffrey Levine, Dept. of Nuclear Medicine, Presbyterian-University Hospital, 230 Lothrop St., Pittsburgh, PA 15213.

ABSTRACT

Dimercaprol (BAL) administered 1 hr before ¹¹¹In-bleomycin in the normal BALB/c mouse produced an early and preferential hepatic loading of ¹¹¹In-bleomycin without a loading of the spleen, skin, bone, or muscle. Liver-to-muscle ratios were increased about threefold under the influence of BAL. Liver (c BAL)/liver (s BAL) ratios also increased threefold at 3 hr whereas relative muscle uptake remained at about unity. Indium-111 chloride (colloid, pH 6.5) used as a control did not show a similar increase. The findings suggest that the kinetics and distribution of ¹¹¹In-bleomycin in the normal BALB/c mouse can be influenced by pretreatment with BAL.