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Calculation of Coronary Blood Flow from Myocardial Clearance of Systemically Administered ¹³³Xe

Veterans Administration Hospital and University of Oregon Medical School, Portland, Oregon

Correspondence: For reprints contact: Delmar J. Mahler, Nuclear Medicine Service, Veterans Administration Hospital, Sam Jackson Park, Portland, OR 97207.

ABSTRACT

Clearance curves for arterial and coronary-venous blood were determined after systemic left-ventricle or pulmonary-artery injections of ¹³³Xe, paired with selective left-coronary-artery injections of ¹³³Xe in 20 dogs with closed chest. Coronary blood flows calculated from systemic and coronary-artery injections were comparable only when a correction was made for arterial recirculation of ¹³³Xe following the systemic injection (r = 0.962 for left ventricle and 0.932 for pulmonary artery, paired with coronary artery). Experiments in four other dogs verified that clearance of ¹³³Xe from the pulmonary circulation was only about 60%. The myocardium/blood ¹³³Xe partition coefficient, determined in vivo in ten dogs, agreed within 10% with that previously determined in vitro.