HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by van den Akker, H. P. Articles by van der Schoot, J. B. Search for Related Content PubMed PubMed Citation Articles by van den Akker, H. P. Articles by van der Schoot, J. B.

Origin and Location of the Oral Activity in Sequential Salivary Gland Scintigraphy with ^99mTc-Pertechnetate

University of Amsterdam, Amsterdam, The Netherlands

Correspondence: For reprints contact: E. Busemann Sokole, Dept. of Nuclear Medicine, University Hospital "Wilhelmina Gasthuis," le Helmersstraat 104, Amsterdam, The Netherlands.

ABSTRACT

Conflicting views exist regarding the origin and location of the oral radio activity seen in salivary gland scintigraphy with ^99mTc-pertechnetate. The normal accumulation of oral activity was studied in a series of healthy subjects by sequential scintigraphy (anterior and lateral views) after intravenous injection of 2 mCi of ^99mTc-pertechnetate. Ligation of the parotid ducts and/or cannulation of the submandibular ducts, which prevented their secretions from reaching the oral cavity, established that the oral activity was due entirely to radioactive saliva secreted by the parotid and submandibular glands. Pertechnetate mouthwash studies confirmed that radioactive saliva is adsorbed to oral mucosa and that adsorption to the lingual mucosa is the major contributor to the oral activity. Pertechnetate uptake in sublingual and minor salivary glands of the oral cavity was not visualized, thereby invalidating scintigraphy in the study of these glands. In the diagnosis of salivary gland disorders, oral activity is a useful indicator of major salivary gland function.

This article has been cited by other articles:

				W. Aung, Y. Murata, R. Ishida, Y. Takahashi, N. Okada, and H. Shibuya Study of Quantitative Oral Radioactivity in Salivary Gland Scintigraphy and Determination of the Clinical Stage of Sjogren's Syndrome J. Nucl. Med., January 1, 2001; 42(1): 38 - 43. [Abstract] [Full Text] [PDF]