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Color Functional Images of the Cerebral Blood Flow

Tokyo Metropolitan Geriatric Hospital and IBM Scientific Center, Tokyo, Japan

Correspondence: For reprints contact: Hinako Toyama, Dept. of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173, Japan.

ABSTRACT

Functional gamma imaging, in color, was established for regional cerebral blood flow (rCBF) using ¹³³Xe. During 10 min after intracarotid injection of ¹³³Xe Xe in saline, 60 picture frames of the ¹³³Xe clearance curve for the entire hemisphere were obtained. After nine-point smoothing, the rCBF for each of the 4,096 picture elements was calculated by two methods: the half-time method and the height-over-area method. Both the ¹³³Xe clearance half-times and the calculated CBF values were displayed, using 13 steps of color, as functional CBF images of the brain. Images of peak count and total count were also displayed on the same frame of the color television. Forty-six studies, performed on 37 patients with various cerebral disorders, were divided into two types: diffuse and focal. In the diffuse type, a decrease in CBF was noted in cases of normal-pressure hydrocephalus; successful ventriculoperitoneal shunt operations were followed by recovery of CBF. Occlusion of the middle cerebral artery showed up as a wedge-shaped area of decreased CBF, even when the conventional brain scan looked normal. Increased perfusion to a tumor was frequently associated with decreased CBF in the rest of the lateral hemisphere; such a decrease could be improved by surgical removal of the tumor.