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The Journal of Nuclear Medicine Vol. 17 No. 11 1003-1007
© 1976 by Society of Nuclear Medicine
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New 68Ga-Labeled Skeletal-Imaging Agents for Positron Scintigraphy

Mrinal K. Dewanjee, Donald J. Hnatowich and Robert Beh

Mayo Clinic, Rochester, Minnesota, and Massachusetts General Hospital, Boston, Massachusetts

Correspondence: For reprints contact: D. J. Hnatowich, Physics Research Laboratory, Massachusetts General Hospital, Boston, MA 02114.

ABSTRACT

The present skeletal-imaging agents labeled with radiogallium rely upon carrier gallium to augment bone uptake; no gallium-labeled bone-imaging agent free of this disadvantage is available. In attempts to develop such agents, we prepared 68Ga-ethylenediaminetetramethylene phosphonate (68Ga-EDTMP) and 68Ga-diethylenetriaminepentamethylene phosphonate (68Ga-DTPMP) and determined their biologic distributions in rats and dogs. These compounds combine the bone-seeking characteristics of phosphonic acid and the complexing ability of EDTA and DTPA analogs. The chelates are administered without gallium carrier. In rats, 50–60% of the carrier-free dose accumulates in bone at 1 hr after intravenous injection, while 25–30% is excreted through the urine. In dogs, at 3 hr after intravenous injection 35% is found in bone. Although the general patterns of organ distribution of the two 68Ga chelates are similar, 68Ga-EDTMP appears superior because of its faster blood clearance. Bone images obtained with this compound in dogs, using a multidetector positron camera, are presented. The optimum time for imaging was found to be 2.5–3 hr after injection.






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Copyright © 1976 by the Society of Nuclear Medicine.