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Quality Assurance for ^99mTc-Sn-Pyrophosphate

Veterans Administration Hospital and University of Minnesota School of Medicine, Minneapolis, Minnesota

Correspondence: For reprints contact: R. B. Shafer, Nuclear Medicine Service, Veterans Administration Hospital, 54th St. and 48th Ave. South, Minneapolis, MN 55417.

ABSTRACT

Because skeletal images obtained with a commercial lyophilized preparation of ^99mTc-Sn-pyrophosphate were occasionally degraded by liver and spleen uptake, a method for preparing ^99mTc-Sn-pyrophosphate and a system for in-house quality assurance were developed. Control of the age of the stannous chloride solution and the final pH of the ^99mTc-Sn-pyrophosphate eliminated the undesirable uptake. The quality and body distribution of the in-house preparation were compared to those of the radiopharmaceutical from a commercial kit.