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^99mTc-Bioquin-7CA, a Potential New Hepatobiliary Scanning Agent

Vancouver General Hospital, Vancouver, British Columbia, Canada

Correspondence: For reprints contact: Donald M. Lyster, Div. of Nuclear Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada.

ABSTRACT

The complex ^99mTc-Sn-8-hydroxyquinoline-7-carboxylate (^99mTc-bioquin-7CA) was investigated in animals as a potential hepatobiliary scanning agent. Following intravenous injection, the complex was found to localize in the liver rapidly and in the gallbladder in 5–15 min; after 15 min it was excreted into the biliary tract with a high degree of specificity. Urinary excretion was negligible, reducing scan interference from the kidneys. Distribution studies in mice compared well with the localization of activity observed in rabbit scans. Preparation of the complex was rapid and simple; stannous ion was used as the reducing agent.