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Intercomparison of Myocardial Imaging Agents: ²⁰¹TI, ¹²⁹Cs, ⁴³K, and ⁸¹Rb

Nuclear Medicine Laboratory, Bureau of Radiological Health, and University of Cincinnati, Cincinnati General Hospital, Cincinnati, Ohio

Correspondence: For reprints contact: H. Nishiyama, Nuclear Medicine Laboratory, Cincinnati General Hospital, Cincinnati, OH 45267.

ABSTRACT

Thallium-201, ¹²⁹Cs, ⁴³K, and ⁸¹Rb were evaluated as "static" myocardial-imaging agents. Optimal settings of the scintillation camera were determined for each agent. Accumulation for good-quality images can be started as early as 5 min after the dose with ⁴³K, 10 min with ²⁰¹Tl, and 30 min with ¹²⁹Cs. Imaging times were comparable for ⁴³K, ¹²⁹Cs, and ²⁰¹Tl (using the 80-keV x-rays). High-energy photons from the ⁸¹Rb preparation, largely from ^82mRb contaminant, made it impossible to obtain an interpretable image without the addition of more shielding. Absorbed radiation dose from ⁸¹Rb is lower than that from ⁴³K, ¹²⁹Cs, and ²⁰¹Tl. The highest background activity was observed with ⁸¹Rb, followed by ⁴³K, ¹²⁹Cs, and ²⁰¹Tl in that order. Overall, ²⁰¹Tl was best suited for imaging acute myocardial infarction with currently available equipment, and ¹²⁹Cs was next best. However, because of instrument setting and commercially obtained preparations, ⁸¹Rb could not be properly compared with the other radionuclides in our study.

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