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A Simple Technique for Measuring Relative Renal Blood Flow

University of California School of Medicine, San Francisco, California

Correspondence: For reprints contact: David M. Shames, Sect. of Nuclear Medicine, Dept. of Radiology, 380-M, University of California School of Medicine, San Francisco, CA 94143.

ABSTRACT

To determine whether externally monitored early renal uptake of ¹³¹I-hippurate is proportional to renal blood flow, the renal uptake of ¹³¹I-hippurate at 1–2 min after injection was compared with the renal accumulation of radioactive carbonized microspheres in dogs. A renal artery catheter equipped with a balloon was used to decrease renal blood flow unilaterally. One minute after the intravenous injection of 100 µCi of ¹³¹I-hippurate, about 1 µCi of either ⁸⁵Sr- or ⁹⁵Nb-labeled carbon microspheres was injected into the left ventricle. Radioactivity was measured over both kidneys. The total radioactivity within each kidney region of interest was corrected for background and integrated over the 1–2-min interval after injection. Thirteen measurements of relative renal blood flow were made for seven dogs. The dogs were then killed and both kidneys were excised and counted for the radioactivity of the microspheres. The 1–2-min relative renal uptake of ¹³¹I-hippurate correlated well with relative microsphere uptake, suggesting that relative renal blood flow can be simply determined from the external measurement of renal uptake of ¹³¹I-hippurate.

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				W. Geng and K. S. Pang Differences in Excretion of Hippurate, as a Metabolite of Benzoate and as an Administered Species, in the Single-Pass Isolated Perfused Rat Kidney Explained J. Pharmacol. Exp. Ther., February 1, 1999; 288(2): 597 - 606. [Abstract] [Full Text]