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Labeling of Tin-Soaked Albumin Microspheres with ⁶⁸Ga

Massachusetts General Hospital, Boston, Massachusetts

Correspondence: For reprints contact: Donald J. Hnatowich, Physics Research Laboratory, Massachusetts General Hospital, Boston, Mass. 02114.

ABSTRACT

A method is described for the labeling of tin-soaked human serum albumin microspheres with ⁶⁸Ga. The radionuclide is a short-lived (T_1/2 = 68 min) generator product and a positron emitter; the labeled particles may be used for perfusion studies with a positron camera. The labeling procedure requires 40 min after elution of the ⁶⁸Ga generator and provides a labeling efficiency of 90 ± 5%. The in vivo stability of the particles was determined in a series of animal experiments which showed little washout of lung activity over a 2-hr period.