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Technetium-99m-pyridoxylideneglutamate, a New Agent for Gallbladder Imaging: Comparison with ¹³¹I-rose Bengal

Washington Hospital Center and George Washington University, Washington, D.C.

Correspondence: For reprints contact: W. C. Eckelman, Nuclear Medicine Research, George Washington University, Walter G. Ross Hall—Room 225, Washington, D.C. 20037.

ABSTRACT

Two agents used for hepatobiliary studies, ¹³¹I-rose bengal and ^99mTc-pyridoxylideneglutamate, have been compared in rabbits. The ^99mTc radiopharmaceutical is rapidly cleared from the blood by the liver and rapidly excreted through the common bile duct into the duodenum. Because of its rapid removal from the liver, visualization of the gallbladder and biliary passages was obtained within 15 min after injection in experimental animals.