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Measurement of Acute Myocardial Infarcts in Dogs with ^99mTc-stannous Pyrophosphate Scintigrams

Parkland Memorial Hospital and the University Texas Health Science Center at Dallas, Dallas, Texas

Correspondence: For reprints contact: Ernest M. Stokely, Ischemic Heart Center, L5-134, University of Texas Health Science Center at Dallas, 5323 Harry Hines Blvd., Dallas, Tex. 75235.

ABSTRACT

Myocardial scintigrams using ^99mTc-stannous pyrophosphate (^99mTc-PYP) can be used to measure myocardial infarcts produced in dogs by proximal ligation of the left anterior descending coronary artery. Seven dogs had ^99mTc-PYP myocardial scintigraphy performed 24–32 hr after ligation of the proximal left anterior artery. In each dog the scintigrams showed increased ^99mTc-PYP uptake in the distribution of the artery. The scintigraphically visible areas of infarction, measured using interactive computer-aided techniques, were compared subsequently with independent histologic measurements of myocardial infarct size. Several methods for using the area measurements to estimate infarct size were tested. The most sucsuccessful method (r = 0.92, p < 0.01) assumed a linear relationship between the largest scintigraphic infarct area and the histologically determined infarct weight. The results suggest that ^99mTc-PYP myocardial scintigrams provide a useful noninvasive method for measuring infarct size in dogs with proximal ligation of the left anterior descending coronary artery.

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