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Xenon-133, ¹²⁷Xe, and ¹²⁵Xe for Lung Function Investigations: A Dosimetric Comparison

Southampton General Hospital, Southampton, England

Correspondence: For reprints contact: Duncan Ackery, Wessex Regional Dept. of Nuclear Medicine, Southhampton General Hospital, Shirley, Southampton S09 4XY, England.

ABSTRACT

Of the possible radionuclides of xenon, ¹²⁷Xe and ¹²⁵Xe have better physical properties for lung function measurement than ¹³³Xe. A comparison of the radiation doses for these three radionuclides has been made for a typical scintillation camera investigation. Using an exponential model for washin and washout of gas, it is shown that the specific activity-time relationship is always equal to the product of the spirometer concentration and the rebreathing period.

It is concluded that of the three radionuclides ¹²⁷Xe gives the lowest radiation dose during a typical lung function study.

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