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Tissue Distribution of ¹⁴C-, ¹²⁵I-, and ¹³¹I-Diphenylhydantoin in the Toadfish, Rat, and Human with Insulinomas

The University of Michigan, Ann Arbor, Michigan

Correspondence: For reprints contact: William H. Beierwaltes, Div. of Nuclear Medicine, The University of Michigan Medical Center, 1405 E. Ann St., Ann Arbor, Mich. 48104.

ABSTRACT

Carbon-14-diphenylhydantoin (DPH) concentrated maximally in pancreatic islet cells of the toadfish 10 min after its intravenous administration. The islet cell-to-acinar-tissue ratio at this time was 6:1. The islet cell-to-liver ratio was 20:1. Iodine-125-paraiodo-DPH at 10 min in the toadfish showed an islet cell-to-acinar-tissue ratio of 1.7:1 and an islet cell-to-liver ratio of 2.3:1. When ¹⁴C-DPH was given to four patients 10–17 min before removal of normal pancreatic tissue and of an insulinoma in three of the patients, the concentration of radioactivity in the insulinoma was never greater than in, the pancreas and concentrations in insulinoma and pancreas were always less than in liver in the same individual. Forty-five to 90 min after administration of ¹³¹I-DPH, the liver and pancreas were delineated in three patients but the insulinoma was not imaged. Five days after administration of ¹³¹I-DPH, the concentration of ¹³¹I radioactivity in excised tissue was greater in the insulinomas than in the pancreas of two patients and greater than in liver of one patient but not sufficient to produce positive images of the insulinoma in the pancreas.

FOOTNOTES

^* Present address: Div. of Nuclear Medicine, Michael Reese Hospital and Medical Center, Chicago, Ill. 60616.