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A Method for the Preparation and Quality Control of ⁶⁸Ga Radiopharmaceuticals

Massachusetts General Hospital, Boston, Massachusetts

Correspondence: For reprints contact: Donald J. Hnatowich, Physics Research Laboratory, Massachusetts General Hospital, Boston, Mass. 02114.

ABSTRACT

Gallium-68 (T_1/2 68 min) is a convenient label for radiopharmaceuticals designed for use with positron detection devices ; the radionuclide is a generator product obtained from its parent ⁶⁸Ge (T_1/2 287 days). The labeling procedure itself is simple since gallium forms complexes without the use of reducing agents. However, ⁶⁸Ga is present in the generator eluant as the gallium-EDTA chelate and must be separated from EDTA prior to its use as a label. A rapid and efficient method for achieving this separation and for preparing ⁶⁸Ga-labeled compounds for human use has been developed. Paper chromatography is employed to determine the amount of each major gallium species present in preparations of two gallium complexes; ⁶⁸Ga-adenosine triphosphate and ⁶⁸Ga-citrate.

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