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The Journal of Nuclear Medicine Vol. 16 No. 8 738-743
© 1975 by Society of Nuclear Medicine
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Kinetics of 111In-Bleomycin and 111In-Chlorides in Mice

Tad Konikowski, Thomas P. Haynie and Howard J. Glenn

The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas
University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, Texas

Correspondence: For reprints contact: T. Konikowski, Nuclear Medicine Section, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, 6723 Bertner Blvd., Houston, Tex. 77025.

ABSTRACT

Indium-111 as the chloride and chelated to bleomycin has been reported useful as a tumor scanning agent. This is a report of the kinetics of these compounds compared in Yale-Swiss mice bearing a transplantable, in situ brain sarcoma. Indium-111-chloride, pH 1.5, gave a maximum tumor uptake of 18.5% dose per gram tumor, a maximum tumor-to-brain ratio of 17.0, and a maximum tumor-to-blood ratio of 4.4. Its renal blood clearance was a slow 0.0022 ml/min. Indium-111 -bleomycin showed a maximum tumor uptake of 3.0% dose per gram tumor, a maximum tumor-to-brain ratio of 13.5, a maximum tumor-to-blood ratio of 6.8, and renal blood clearance of 0.254 mi/min. The labeling of bleomycin with 111In results in a tracer with localizing properties in this tumor model which are quite different from those obtained with 111In-chloride. Both 111In as chloride or that labeled to bleomycin would appear to have significant potential as agents for imaging tumors.






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Copyright © 1975 by the Society of Nuclear Medicine.