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The Journal of Nuclear Medicine Vol. 16 No. 8 709-712
© 1975 by Society of Nuclear Medicine
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Phagocytic Capability of the Kidney: A Possible Mechanism for Renal Uptake of Colloid in Liver-Spleen Scanning

Michael A. Mikhael and Ronald G. Evens

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri

Correspondence: For reprints contact: Ronald G. Evens, Mallinckrodt Institute of Radiology, 510 S. Kingshighway, St. Louis, Mo. 63110.

ABSTRACT

Guinea pigs were given Trypan blue or India ink i.v. and i.m. to demonstrate whether proximal convoluted tubule cells of the normal kidney have potential phagocytic capability. Circulating colloidal particles of Trypan blue solution accumulated in these cells and the accumulation was related to the particle size, dose injection, and duration of experiment. These studies suggest an explanation for the clinical observation of renal visualization with 99mTc-sulfur colloid in patients with congestive heart failure.






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Copyright © 1975 by the Society of Nuclear Medicine.