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Chemistry of Technetium Radiopharmaceuticals. I. Exploration of the Tissue Distribution and Oxidation State Consequences of Technetium (IV) in Tc-Sn-Gluconate and Tc-Sn-EHDP Using Carrier ⁹⁹Tc

Donner Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley, California
Howard University, Washington, D.C.

Correspondence: For reprints contact: J. McRae or P. Hambright, Donner Laboratory, University of California, Berkeley, Calif. 94720.

ABSTRACT

The distribution in rats of the renal agent Tc-Sn-gluconate using both ^99mTc and carrier amounts of ⁹⁹Tc was similar. The same behavior was shown with the bone agent Tc-Sn-EHDP. The radiopharmaceutical consequences of the observed Tc(IV) oxidation state in these systems are explored.