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A ⁸²Sr-⁸²Rb Isotope Generator for Use in Nuclear Medicine

University of New Mexico School of Medicine and Los Alamos Scientific Laboratory, Los Alamos, New Mexico

Correspondence: For reprints contact: Patrick M. Grant, Group CNC-11, Los Alamos Scientific Laboratory, P.O. Box 1663, Los Alamos, N. Mex. 87544.

ABSTRACT

An improved ⁸²Sr-⁸²Rb generator system, based on the complexing ion-exchange resin Chelex-100, has been developed. Columns of this material can be easily and rapidly milked, and the rubidium-strontium separation factor for a fresh generator under the experimental conditions studied was found to be >10⁷. Approximately 80% of the ⁸²Rb present can be delivered in a 15-ml volume of aqueous 0.2 M NH₄Cl solution. After more than 6 liters of eluant had passed through the generator, the rubidium-strontium separation factor was still observed to be > 10⁵ and no unusual strontium breakthrough behavior was seen in the system over nearly three ⁸²Sr half-lives.