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Breast Scintigraphy with ^99mTc-Pertechnetate and ⁶⁷Ga-Citrate

National Institutes of Health, Bethesda, Maryland

Correspondence: For reprints contact: Steven D. Richman, Clinical Center, Bldg. 10, Room 1B44A, Dept. of Nuclear Medicine, National Institutes of Health, Bethesda, Md. 20014.

ABSTRACT

Radionuclide breast scintigraphy was evaluated as a noninvasive tumor-localizing modality. Technetium-99m-pertechnetate (^99mTcO₄) demonstrated good correlation between malignancy and positive scintigraphy (88% accuracy in 16 cases of breast carcinoma). The high false-positive rate (29% of proven benign breast disease) limits the use of ^99mTcO₄ as an aid to differential diagnosis. Gallium-67-citrate (⁶⁷Ga) is limited as a diagnostic adjunct (localizing in only five of ten breast malignancies). Refined techniques of positioning, shielding, gamma camera imaging, and computer assistance have helped in visualizing abnormal radionuclide accumulation.