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Dynamic Study of Exocrine Function of the Pancreas in Diabetes Mellitus with Scintigraphy Using ⁷⁵Se-Selenomethionine

Osaka University Medical School, Osaka, Japan

Correspondence: For reprints contact: Mitsuru Hoshi, The First Department of Medicine, Osaka University Medical School, Dojima, Fukushima-ku, Osaka 553, Japan.

ABSTRACT

A dynamic study of scintigraphy of the pancreas using ⁷⁵Se-selenomethionine in diabetic patients was performed. Patients were selected who complained of abdominal pain or diarrhea or both and whose pancreatic exocrine functions were thought to be disturbed. Selenium-75-selenomethionine (3 µCi/kg body weight) was injected intravenously and radioactivity (cpm) was recorded by a scinticamera for 10 min successively up to 120 min. After 20–30 min the increase of radioactivity in the selected area of the displayed pancreas usually reached a plateau. Pancreozymin (1 Harper unit/kg) and secretin (1 Harper unit/kg) were administered intravenously and decrease of radioactivity in the same area was followed for 60 min to examine pancreatic exocrine function. After ⁷⁵Se-selenomethionine injection, the angle of the initial increase of radioactivity, the height of the plateau, and the reactive decrease of radioactivity after pancreozymin and secretin were analyzed in each case. Radioactivity recorded on data tape was reproduced for each 10-min period on a cathode-ray tube display. Areas of interest were selected for dynamic analyses. To supplement the diagnosis by visual image of a scintigram of the pancreas, the scintigram was quantified in the present study and the dynamic curves of radioactivity in the selected area of the displayed pancreas were studied for a total of 3 hr. Application of the dynamic study of the pancreas scintigraphy and the additional data analyses seemed useful for the early detection of pancreatic exocrine dysfunction in diabetic patients in whom the ordinary laboratory pancreatic exocrine function tests gave uncertain results.