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Relative Tissue Distribution of Radioactivity in Rats with Endocrine "Autonomous" Breast Carcinomas after ³H-, ^99mTc-, and ⁶⁴Cu-Bleomycin

The University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: For reprints contact: W H. Beierwaltes, Nuclear Medicine Div., University of Michigan Medical Center, 1405 E. Ann St., Ann Arbor, Mich. 48104.

ABSTRACT

The localization of ⁶⁴Cu-, ³H-, and ^99mTc-labeled bleomycin was studied in tissues of Fisher rats bearing an endocrine autonomous breast tumor. The ⁶⁴Cu-bleomycin showed a greater uptake than ³H- and ^99mTc-bleomycin in the breast tumor at all time intervals studied, from 2 to 72 hr after the tracer. This same differential uptake was shared by the liver and kidney.

FOOTNOTES

^* Present address: Div. of Nuclear Medicine, Michael Reese Hospital and Medical Center, Chicago, Ill. 60616.