HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zweiman, F. G. Articles by Idoine, J. Search for Related Content PubMed PubMed Citation Articles by Zweiman, F. G. Articles by Idoine, J.

Selective Uptake of ^99mTc Complexes and ⁶⁷Ga in Acutely Infarcted Myocardium

Harvard Medical School and Peter Bent Brigham Hospital, Boston, Massachusetts

Correspondence: For reprints contact: B. Leonard Holman, Dept. of Radiology, Harvard Medical School, 25 Shattuck St., Boston, Mass. 02115.

ABSTRACT

The suitability of various radiopharmaceuticals (^99mTc-tetracycline analogs, ^99mTc-glucoheptonate, ^99mTc-disphosphonate, and ⁶⁷Ga-citrate) for use in imaging acute myocardial infarction was assessed by determining their biologic distributions in experimentally infarcted dogs. The highest infarct-to-normal myocardial concentration ratio was found with ^99mTc-diphosphonate (27.9:1); the highest infarct-to-liver ratio was also found with ^99mTc-diphosphonate (15.9:1). The infarct-to-bone ratio, however, was 0.4:1 with ^99mTc-diphosphonate. There was an excellent positive linear correlation between blood-flow reduction and uptake of the radiopharmaceutical after a threshold reduction in blood flow with ^99mTc-glucoheptonate and ^99mTc-tetracycline. Technetium-99m-tetracycline accumulated only in infarcted tissue while ^99mTc-diphosphonate was increased in both ischemic and infarcted tissue. Thus, ^99mTc-diphosphonate has characteristics best suited for scintigraphic imaging. Since ^99mTc-tetracycline accumulates only in infarcted tissue, however, this tracer more accurately defines the size of an acute infarction.