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Dosimetry of Four Heart-Imaging Radionuclides: ⁴³K, ⁸¹Rb, ¹²⁹Cs, and ²⁰¹Tl

Bureau of Radiological Health, Food and Drug Administration, Cincinnati General Hospital, Cincinnati, Ohio

Correspondence: For reprints contact: Paul A. Feller, Nuclear Medicine Laboratory, BRH, FDA, Cincinnati General Hospital, Cincinnati, Ohio 45267.

ABSTRACT

In conjunction with research into the relative clinical suitability of radionuclides for heart imaging, estimates of the radiation dosimetry for ⁴³K, ⁸¹Rb, ¹²⁹Cs, and ²⁰¹Tl were calculated. Estimates of absorbed radiation dose for the heart, kidneys, liver, lungs, testes, and whole body of the standard man were computed from published distribution data in rats via the MIRD method by assuming that the concentration in each organ per initial mean whole-body concentration is the same in rats and humans. The whole-body absorbed radiation doses from ⁸¹Rb, ¹²⁹Cs, ²⁰¹Tl, and ⁴³K are 0.08, 0.17, 0.24, and 0.60 rads/mCi administered intravenously. In general, the organ doses for the four radionuclides follow the same order.