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Some Experience with ⁵⁷Co-Labeled Bleomycin as a Tumor-Seeking Agent

University Hospital, Groningen, The Netherlands

Correspondence: For reprints contact: M. G. Woldring, Isotopenlaboratorium der Rijksuniversiteit te Groningen, Groningen, The Netherlands.

ABSTRACT

Bleomycin labeled with ⁵⁷Co was used as a tumor-localizing agent in 132 patients. In patients with pulmonary tumors the primary to causation concentrated radioactivity in 52 of the 54 appropriate cases; out of the 22 clinically known metastases, 19 were visible on the scan; 40 unknown metastases especially in hilus and mediastinum were found by this method and subsequently confirmed. In 22 patients with malignant lymphomas, 18 out of 22 known pathologic lymph glands above the diaphragm were visible on the scan; below the diaphragm the results of scanning in lymph glands and spleen were disappointing, probably because of the disturbing concentration of radioactivity in the kidneys, the bladder, the liver, and some times the gut. In 25 patients with various other tumors, 16 out of 22 known localizations above the diaphragm were visible; 2 were uncertain and 4 negative. Below the diaphragm the results were usually negative. In 24 patients with benign lesions, uptake of ⁵⁷Co-bleomycin was visible on the scintigram in 4 patients with cavitating pulmonary tuberculosis, in 2 with pulmonary infections, in 1 with Caplan lesions of rheumatoid arthritis in the lung, and in 1 with sinusitis ethmoidalis. The significance of these results is discussed.