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Sodium Trimetaphosphate as a Bone-Imaging Agent. I. Animal Studies

Vanderbilt University, Nashville, Tennessee

Correspondence: For reprints contact: John R. Van Wazer, Vanderbilt University, Nashville, Tenn. 37235.

ABSTRACT

When used in conjunction with stannous ion and ⁹⁹Tc, the nonsequestering, cyclic, trimeric phosphate anion, (P₃O₉)^3–, introduced in the form of its sodium salt, exhibits admirable properties as a bone-visualizing agent as demonstrated by animal studies. These studies show that this combination is easily prepared reproducibly and, compared to the agents described in the recent literature (all based on sequestering phosphates), is at least equivalent for bone visualization while being considerably less toxic.