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"Cold" Lesions on Bone Imaging

Brooklyn-Cumberland Medical Center and Downstate Medical School, SUNY, Brooklyn, New York

Correspondence: For reprints contact: Wilfrido M. Sy, Nuclear Medicine Service, Brooklyn-Cumberland Medical Center, 121 DeKalb Ave., Brooklyn, N.Y. 11201.

ABSTRACT

Photon-deficient foci or "cold" lesions were demonstrated on ^99mTc-polyphosphate bone imaging in eight individuals with various malignancies and one in sickle cell crisis. The bone radiographs of five of these persons failed to show corresponding bony changes at the time of the imaging. Most of the "cold" lesions observed on bone imaging were located in the denser and tubular bones.

A postulate has been advanced regarding the factors that might influence the different gamma-imaging manifestations of radiographically demonstrable lytic lesions.

The cases presented herein further emphasize the importance of recognizing the existence of "cold" areas in the images of bones and the need to place these in proper perspective when interpreting scans.